January 1, 2011Hormone Research in Paediatrics

Diagnosis of Glucocorticoid-Remediable Aldosteronism in Hypertensive Children

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Population

3 children of a family with primary aldosteronism

Design

Case_series

Authors

CKClemens KamrathUniversity of Freiburg CMChristiane Maser‐GluthHeidelberg University CHChristine HaagUniversity of Cologne

Discussion

Member takes

Implication

Supports targeted genetic testing in familial low-renin hypertension; leaves open broader screening utility pending larger studies.

Structured PICO

Population

3 children of a family with primary aldosteronism

Intervention

Dexamethasone suppression test, serum 18-OHF determination, measurement of urinary excretion of aldosterone, its metabolites and 18-OHF, and polymerase chain reaction (PCR) for chimeric gene

Outcome

Identification of the CYP11B1/CYP11B2 chimeric gene and biochemical response to dexamethasonesurrogate

Genetic testing for the CYP11B1/CYP11B2 chimeric gene provides a definitive diagnosis of glucocorticoid-remediable aldosteronism in children with low-renin hypertension.

Cite This Study

Kamrath et al. (2011) studied this question.

synapsesocial.com/papers/6a850d5751af2ae1db8aa7cb https://doi.org/10.1159/000326524

Topics

Hypertension management

View Full Paper

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Diagnosis of Glucocorticoid-Remediable Aldosteronism in Hypertensive Children

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Diagnosis of Glucocorticoid-Remediable Aldosteronism in Hypertensive Children

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider