Why the study?
Does candesartan improve cardiac function and prevent microangiopathy in a diabetic rat model?
Population
Male Otsuka Long-Evans Tokushima Fatty rats, a model of spontaneously developing diabetes mellitus, and…
Comparison
Candesartan 0.2 mg/kg/day for six weeks vs Vehicle for six weeks
Design
Preclinical
Follow-up
6 weeks
Authors
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Candesartan may preserve diastolic function in diabetic rat cardiomyopathy; hypothesis-generating for clinical ARB trials.
Does candesartan improve cardiac function and prevent microangiopathy in a diabetic rat model?
In a diabetic rat model, angiotensin II receptor blockade with candesartan preserved left ventricular diastolic function and prevented cardiac microangiopathy.
Tatsuya Hayashi (2003) studied this question.
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