Why the study?
To elucidate the structural basis for differences in replication rates and fidelity among different viruses using chimeric picornaviral RNA-dependent RNA polymerases.
Population
Chimeric RdRPs from poliovirus and coxsackievirus B3
Comparison
Exchange of fingers, pinky finger, or thumb domains
Design
Biochemical, rapid-quench, and stopped-flow assay study
Authors
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Structural insights into RdRP fidelity extend basic virology; leaves open any clinical translation.
Differences in biochemical activity of picornaviral RdRPs map to individual modular domains, providing insights into viral replication mechanisms.
Watkins et al. (2020) studied this question.
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