August 22, 2019Frontiers in MicrobiologyOpen Access

A Structure-Function Diversity Survey of the RNA-Dependent RNA Polymerases From the Positive-Strand RNA Viruses

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Why the study?

Functional regions fused to viral RdRP catalytic modules create diversity in structure and regulation, but knowledge regarding these additional regions is limited.

Population

46 representative RdRPs from 43 virus families of positive-strand RNA viruses

Design

Review and sequence-structure survey

Authors

HJHengxia JiaChinese Academy of Sciences PGPeng GongNankai University

Discussion

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Implication

N-terminal RdRP fusions predominate yet remain structurally unresolved beyond Flaviviridae; leaves open their roles in replication and antiviral targeting.

Structured PICO

Population

46 representative RNA-dependent RNA polymerases (RdRPs) from 43 RdRP-sequence available virus families of positive-strand RNA viruses listed in the 2018 ICTV collection

This review maps the structural and functional diversity of RdRPs across positive-strand RNA viruses, highlighting the need for future full-length structural studies.

Cite This Study

Jia et al. (2019) studied this question.

synapsesocial.com/papers/6a840d869cea0905630b9682 https://doi.org/10.3389/fmicb.2019.01945

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Implication

N-terminal RdRP fusions predominate yet remain structurally unresolved beyond Flaviviridae; leaves open their roles in replication and antiviral targeting.

A Structure-Function Diversity Survey of the RNA-Dependent RNA Polymerases From the Positive-Strand RNA Viruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

A Structure-Function Diversity Survey of the RNA-Dependent RNA Polymerases From the Positive-Strand RNA Viruses

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider