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This review describes the structure and functional significance of viral RNA-dependent RNA polymerases obtained from X-ray analysis, focusing primarily on picorna-, flavi-, and caliciviruses.
This review summarizes the structural organization and functional significance of viral RNA-dependent RNA polymerases, primarily focusing on picorna-, flavi-, and caliciviruses.
Structural insights into viral RdRPs may guide antiviral design; leaves open clinical validation in picorna-, flavi-, and calicivirus infections.
This review describes available data on the structure of viral RNA-dependent RNA polymerases (RdRP) obtained from X-ray analysis and discusses the functional significance of the structural elements of these enzymes. Because most of the studies done to date relate to RdRP structures of picorna-, flavi-, and caliciviruses, here we consider mostly the structures of RdRP of these groups of viruses, and also include information about polymerases of other virus families.
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Shatskaya et al. (2013) conducted a review in Viral RNA-dependent RNA polymerases. This review describes the structure and functional significance of viral RNA-dependent RNA polymerases obtained from X-ray analysis, focusing primarily on picorna-, flavi-, and caliciviruses.
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