FMDV RNA-dependent RNA polymerase forms higher-order fibril structures in vitro that are dependent on active elongation, suggesting a structural mechanism for viral replication factories.
The replication of many viruses involves the formation of higher-order structures or replication "factories." We show that the key replication enzyme of foot-and-mouth disease virus (FMDV), the RNA-dependent RNA polymerase, forms fibrils in vitro. Although there are similarities with previously characterized poliovirus polymerase fibrils, FMDV fibrils are narrower, are composed of both protein and RNA, and, importantly, are seen only when all components of an elongation assay are present. Furthermore, an inhibitory RNA aptamer prevents fibril formation.
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Bentham et al. (2011) studied this question.
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