Key result
The crystal structure of the foot-and-mouth disease virus 3D polymerase reveals characteristic fingers, palm, and thumb subdomains with conserved amino acids binding to the template-primer RNA.
The crystal structure of the foot-and-mouth disease virus 3D polymerase provides essential information for understanding RNA replication and designing antiviral compounds.
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Provides basis for FMDV antiviral design; leaves open translation to effective therapies in vivo.
Ferrer‐Orta et al. (2004) studied Foot-and-mouth disease virus. The crystal structure of the foot-and-mouth disease virus 3D polymerase reveals characteristic fingers, palm, and thumb subdomains with conserved amino acids binding to the template-primer RNA.
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