Population
Poliovirus mutants and HeLa cells
Design
Preclinical
Authors
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May limit soluble receptor antivirals via resistant mutants; leaves open their in vivo pathogenicity and clinical relevance.
The use of soluble receptors as antiviral agents could lead to the selection of neutralization-resistant poliovirus mutants that can still replicate and cause disease.
Kaplan et al. (1990) studied this question.
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