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Epac proteins' vascular roles merit mechanistic study; leaves open clinical translation or targeted therapies in cardiovascular disorders.
The article contains a review of published data on the contribution of Epac proteins to the physiology and pathological processes of the cardiovascular system. Part 1 of the review is focused on the structure of regulatory Epac proteins and their role in the regulation of vascular tone and permeability, angiogenesis, proliferation of endotheliocytes and smooth myocytes, and pathogenesis of vascular disorders.
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Kryzhanovsky et al. (2020) studied this question.
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