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January 23, 2014Biochemical Society Transactions

cAMP signalling in the vasculature: the role of Epac (exchange protein directly activated by cAMP)

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OROwain RobertsCDCaroline Dart

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Overview

Epac proteins may represent novel cAMP targets in vascular disease; leaves open clinical translation pending interventional studies.

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Cite This Study

Roberts et al. (2014) studied this question.

synapsesocial.com/papers/6a85123b0771a786ab54ddaehttps://doi.org/10.1042/bst20130253
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exchange protein activated by cAMP (Epac) mediates cAMP‐dependent but protein kinase A‐insensitive modulation of vascular ATP‐sensitive potassium channels2009 · 67 citations
  2. 2The Epac1 Protein: Pharmacological Modulators, Cardiac Signalosome and Pathophysiology2019 · 40 citations
  3. 3Epac as a tractable therapeutic target2023 · 20 citations
  4. 4Epac and PKA: a tale of two intracellular cAMP receptors2008 · 363 citations
  5. 5cAMP-Binding Protein Epac Induces Cardiomyocyte Hypertrophy2005 · 181 citations