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June 3, 2009The Journal of PhysiologyOpen Access

Exchange protein activated by cAMP (Epac) mediates cAMP‐dependent but protein kinase A‐insensitive modulation of vascular ATP‐sensitive potassium channels

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Population

Isolated rat aortic smooth muscle cells

Design

Preclinical

Authors

GPGregor I. PurvesTKTomoko KamishimaLDLowri M. Davies

Discussion

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Overview

Epac activation inhibits vascular KATP via Ca2+ in arterial myocytes; leaves open translation to human physiology or tone regulation.

Structured PICO

P
Population
Isolated rat aortic smooth muscle cells
I
Intervention
Epac-specific cAMP analogue 8-pCPT-2'-O-Me-cAMP, or adenylyl cyclase activator forskolin in the presence of PKA inhibitors (Rp-cAMPS or KT5720)
O
Outcome
Pinacidil-evoked whole-cell KATP currents and intracellular Ca2+ levelssurrogate

Epac activation modulates vascular KATP channel activity via a Ca2+-dependent mechanism involving calcineurin, revealing a novel cAMP-dependent regulatory pathway in arterial smooth muscle.

Cite This Study

Purves et al. (2009) studied this question.

synapsesocial.com/papers/6a70dd0ee5469ee92be189b9https://doi.org/10.1113/jphysiol.2009.173534
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Depotentiation of intact rat cardiac muscle unmasks an Epac‐dependent increase in myofilament Ca<sup>2+</sup> sensitivity2015 · 13 citations
  2. 2The cAMP binding protein Epac regulates cardiac myofilament function2009 · 85 citations
  3. 3The cAMP binding protein Epac modulates Ca 2+ sparks by a Ca 2+ /calmodulin kinase signalling pathway in rat cardiac myocytes2007 · 212 citations
  4. 4Role of the cAMP sensor Epac as a determinant of K<sub>ATP</sub> channel ATP sensitivity in human pancreatic β‐cells and rat INS‐1 cells2008 · 111 citations
  5. 5EPAC1 and 2 inhibit K<sup>+</sup> currents via PLC/PKC and NOS/PKG pathways in rat ventricular cardiomyocytes2024 · 1 citations