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November 4, 2005Circulation ResearchOpen Access

cAMP-Binding Protein Epac Induces Cardiomyocyte Hypertrophy

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Population

Cardiomyocytes (preclinical model)

Design

Preclinical

Authors

ÉMÉric MorelAMAndrea MarcantoniMGMonique Gastineau

Discussion

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Overview

Epac pathway merits testing in hypertrophy models; leaves open any role in human cardiac remodeling or therapy.

Structured PICO

P
Population
Cardiomyocytes (preclinical model)
I
Intervention
Epac activation
O
Outcome
Cardiomyocyte hypertrophy (morphological changes and expression of cardiac hypertrophic markers)surrogate

Epac is identified as a novel positive regulator of cardiac growth, mediating cAMP-induced cardiomyocyte hypertrophy via Rac and calcineurin/NFAT signaling.

Cite This Study

Morel et al. (2005) studied this question.

synapsesocial.com/papers/6a83a65720cfb2932ffe184dhttps://doi.org/10.1161/01.res.0000194325.31359.86
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Also Consider

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  1. 1Ras Regulates NFAT3 Activity in Cardiac Myocytes2001 · 99 citations
  2. 2Altered focal adhesion regulation correlates with cardiomyopathy in mice expressing constitutively active rac12000 · 182 citations
  3. 3Calcium Signaling Regulates Translocation and Activation of Rac2003 · 198 citations
  4. 4Cyclic AMP Raises Intracellular Ca <sup>2+</sup> in Human Megakaryocytes Independent of Protein Kinase A2002 · 21 citations
  5. 5Epac- and Ca2+-controlled Activation of Ras and Extracellular Signal-regulated Kinases by Gs-coupled Receptors2004 · 106 citations