Key result
Myocardial hypertrophy induced by chronic isoproterenol infusion or pressure overload upregulated Epac1 and Epac2 gene expression in murine models.
Epac gene expression is developmentally regulated and upregulated in cardiac hypertrophy, suggesting a functional role in pathophysiological processes.
No takes yet. Share an insight, caveat, or question.
Does not support Epac modulation in clinical hypertrophy; leaves open its role as remodeling target.
Ulucan et al. (2007) studied Myocardial hypertrophy. Isoproterenol infusion or pressure overload was evaluated on Epac gene expression. Myocardial hypertrophy induced by chronic isoproterenol infusion or pressure overload upregulated Epac1 and Epac2 gene expression in murine models.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: