Why the study?
Is left ventricular torsion increased in young patients with uncomplicated type 1 diabetes compared to healthy controls?
Is left ventricular torsion increased in young patients with uncomplicated type 1 diabetes compared to healthy controls?
Answers are grounded in this paper and cite their sources.
Young patients with uncomplicated type 1 diabetes exhibit increased LV torsion, which is independently associated with impaired myocardial perfusion reserve, suggesting a role for coronary microvascular disease.
OBJECTIVE: We used speckle tracking echocardiography to study the early changes in left ventricular (LV) torsion in young patients with uncomplicated type 1 diabetes and stress magnetic resonance imaging (MRI) to assess its interrelationships with coronary microangiopathy. RESEARCH DESIGN AND METHODS: We recruited 33 asymptomatic subjects with type 1 diabetes and 32 age-matched healthy control subjects. All subjects underwent echocardiograms. Stress MRIs were performed in 30 subjects (8 healthy control subjects) to compute myocardial perfusion reserve index (MPRI). RESULTS: A significant increase in LV torsion (2 +/- 0.7 vs. 1.4 +/- 0.7 degrees /cm, P < 0.05) was identified in longer-term and retinopathy-positive type 1 diabetic subjects (1.9 +/- 0.7 vs. 1.4 +/- 0.7 degrees /cm, P < 0.05) as compared with the healthy control subjects. The MPRI was independently associated with increased LV torsion. CONCLUSIONS: We demonstrate that LV torsion is increased in young patients with uncomplicated type 1 diabetes and that coronary microvascular disease may play a key pathophysiological role in the development of increased LV torsion.
No takes yet. Share an insight, caveat, or question.
Shivu et al. (2009) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: