Identified a common polymorphism in the human minK gene resulting in a Ser to Gly amino acid change.
No immediate clinical action warranted; leaves open functional and arrhythmic relevance of this common minK polymorphism for validation studies.
A gene (minK) that encodes a minimal potassium channel has been cloned recently. We describe in this paper a human minK sequence which differs from the original sequence with a single A-->G at position 112. This resulted in a change from a Ser codon (AGT) to a Gly codon (GGT) and created a new MspAI restriction site. Of the 32 alleles from 16 subjects studied, 25 had this newly discovered sequence and 7 had the previously described sequence.
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Lai et al. (1994) studied this question.
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