The New Penicillins and Their Proper Use

Editorials1 January 1966The New Penicillins and Their Proper UseROBERT G. PETERSDORF, M.D., MARVIN TURCK, M.D.ROBERT G. PETERSDORF, M.D.Search for more papers by this author, MARVIN TURCK, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-64-1-207 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptOne of the truly remarkable developments in contemporary science is the discovery, synthesis, and clinical application of the penicillins. This story began in 1928 when Fleming (1) observed the lytic properties of the mold, Penicillium, on cultures of staphylococci. A full 12 years elapsed, however, before Chain, Florey, Jennings, and Williams (2) and Abraham and associates (3) in 1940 appreciated the potential usefulness of this preparation. Subsequently, penicillin research progressed at a rapid pace. The mold was produced on a large scale, and several members were added to the family by coupling of suitable side chains to fermentations of Penicillium....References1. FLEMING A: On the antibacterial action of cultures of a penicillium. Brit. J. Exp. Path. 10: 226, 1929. Google Scholar2. CHAINFLOREYJENNINGSWILLIAMS EHWMATI: Penicillin as chemotherapeutic agent. Lancet 2: 226, 1940. CrossrefGoogle Scholar3. ABRAHAMCHAINFLETCHERFLOREYGARDNERHEATLEYJENNINGS EPECMHWADNGMA: Further observations on penicillin. Lancet 2: 177, 1941. CrossrefGoogle Scholar4. BATCHELORDOYLENAYLORROBINSON EPFPJHGN: Synthesis of penicillin: 6-amino-penicillanic acid in penicillin fermentations. Nature (London) 183: 257, 1959. CrossrefMedlineGoogle Scholar5. STEWARTNIXONCOLES GTHHHT: A report on clinical use of BRL 1241 in children with staphylococcal and streptococcal infections. Brit. Med. J. 2: 703, 1960. CrossrefMedlineGoogle Scholar6. 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Lancet 1: 509, 1962. CrossrefMedlineGoogle Scholar22. BUNN PA: Allergic reactions to penicillins, new and old, in Antimicrobial Agents and Chemotherapy-1964. Baum-Brumfield, Inc., Ann Arbor, Mich., 1965, pp. 302-309. Google Scholar23. SHELLEY WB: Indirect basophil degranulation test for allergy to penicillin and other drugs. JAMA 184: 171, 1964. CrossrefGoogle Scholar24. PARKER CW: Penicillin allergy. Amer. J. Med. 34: 747, 1963. CrossrefMedlineGoogle Scholar25. GRAVENKEMPERBENNETTBRODIEKIRBY CFJVJLWM: Dicloxacillin. Arch. Intern. Med. (Chicago) 116: 340, 1965. CrossrefMedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAuthors: ROBERT G. PETERSDORF, M.D.; MARVIN TURCK, M.D.Affiliations: Department of Medicine University of Washington School of Medicine Seattle, Wash. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byRespiratory Infections and Antimicrobial TherapyThe New Penicillins and CephalosporinsAnaphylaxis: A consideration in the differential diagnosis of shockAntimicrobial Therapy in Respiratory Tract DiseasesCurrent Therapy of Bacterial Pneumonias 1 January 1966Volume 64, Issue 1Page: 207-212KeywordsPenicillin ePublished: 1 December 2008 Issue Published: 1 January 1966 PDF downloadLoading ...