Population
Voltage-dependent potassium channels (Shaker and Shaw mutants)
Comparison
Substitution of amino acids from Shaw S4 into… vs Wild-type Shaker channels or other mutants
Design
Preclinical
Authors
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No immediate clinical implications; extends mechanistic mapping of S4 residues in potassium channel gating.
Noncharged residues in the S4 segment play a crucial role in Shaker potassium channel gating, where small steric changes can lead to large changes in cooperativity.
Smith‐Maxwell et al. (1998) studied this question.
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