Population
In vitro model using recombinant smooth muscle Myosin light-chain kinase fragments expressed in Escherichia…
Comparison
Asp-777-Glu-972 fragment, Met-816-Glu-972… vs Dephosphorylated myosin without the…
Design
Preclinical
Authors
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May indicate phosphorylation-independent myosin activation in vitro; leaves open physiological relevance in intact systems.
The myosin-binding domain of smooth muscle MLCK, specifically the Ala-796-Ser-815 sequence, stimulates myosin ATPase activity without requiring myosin light chain phosphorylation.
Ye et al. (1999) studied this question.
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