The C-terminal domain of smooth muscle MLCK is essential for binding to the head-tail junction of unphosphorylated myosin, facilitating prompt phosphorylation of the 20-kDa light chain upon activation.
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Findings on MLCK domain function remain preclinical; leaves open whether C-terminal targeting modulates contraction in human vascular disease.
Numata et al. (2001) studied this question.
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