Population
Xenopus oocytes expressing slowly activating I channels, homomeric KCNQ1 channels, and WT/mutant MinK subunits
Comparison
Chromanol HMR 1556 and its enantiomer S5557 vs Homomeric KCNQ1 channels vs heteromeric I…
Design
Preclinical
Authors
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Supports allosteric MinK facilitation of chromanol binding to KCNQ1; hypothesis-generating for selective I(Ks) pharmacology.
The MinK subunit likely acts allosterically to facilitate chromanol binding to the principal KCNQ1 subunit rather than directly participating in drug binding.
Lerche et al. (2000) studied this question.
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