What does this research mean for the field?

Chromanol 293B and its analogues specifically target and inhibit I(sK) protein-induced K+ conductances, which mediate cAMP-induced Cl- secretion in epithelia. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

November 4, 1996FEBS LettersOpen Access

Specific blockade of slowly activating IsK channels by chromanols — impact on the role of IsK channels in epithelia

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Population

Cloned K+ channels expressed in Xenopus oocytes and rat colon crypts

Design

Preclinical

Authors

HSH. SuessbrichCardiovascular Center Frankfurt MBMarkus BleichElectrophysiology DED. EckeUniversity of Freiburg

Discussion

Member takes

Implication

Hypothesis-generating for I(sK) modulation in secretory epithelia; leaves open human translation and clinical relevance.

Structured PICO

Population

Cloned K+ channels expressed in Xenopus oocytes and rat colon crypts

Intervention

Chromanols (including lead chromanol 293B) and azimilide

Outcome

Inhibition of I(sK) channels and cAMP-mediated Cl- secretionsurrogate

Chromanols (such as 293B) and the antiarrhythmic azimilide target I(sK) protein-induced K+ conductances, which play a role in epithelial Cl- secretion.

Cite This Study

Suessbrich et al. (1996) studied this question.

synapsesocial.com/papers/6a1242801a516ab1cee3369b https://doi.org/10.1016/0014-5793(96)01113-1

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Specific blockade of slowly activating IsK channels by chromanols — impact on the role of IsK channels in epithelia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Specific blockade of slowly activating IsK channels by chromanols — impact on the role of IsK channels in epithelia

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider