Time‐dependent block of the slowly activating delayed rectifier K⁺ current by chromanol 293B in guinea‐pig ventricular cells

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Population

Single myocytes dissociated from guinea-pig ventricles

Design

Preclinical

Authors

Discussion

May guide I(Ks)-targeted drug design; leaves open clinical utility in humans.

Population

Single myocytes dissociated from guinea-pig ventricles

Intervention

Chromanol 293B (1 - 100 microM)

Outcome

Mechanism and characteristics of I(Ks) block (rate and extent of decay, half-inhibitory concentration, blocking rate constant)surrogate

Chromanol 293B acts as an open channel blocker of the slowly activating delayed rectifier K+ current (I(Ks)) with a 1:1 binding stoichiometry.

Fujisawa et al. (2000) studied this question.

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