Pneumococcal Meningitis in the Adult

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Article1 October 1961Pneumococcal Meningitis in the AdultClinical, Therapeutic, and Prognostic Aspects in Forty-three PatientsRAY A. OLSSON, JAMES C. KIRBY, M.D., MONROE J. ROMANSKY, M.D., F.A.C.P.RAY A. OLSSONSearch for more papers by this author, JAMES C. KIRBY, M.D.Search for more papers by this author, MONROE J. ROMANSKY, M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-55-4-545 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe pneumococcus is uniquely susceptible to penicillin. Despite widespread use, this antibiotic remains bactericidal for the pneumococcus at low concentrations, and no resistant strains have emerged. The unusual characteristics of this microorganism have resulted in a uniformly low mortality for pneumococcal infections generally, and the virtual disappearance of pneumococcal pneumonia as a therapeutic problem.Pneumococcal meningitis, however, appears to be an exception to these facts. Mortality varies from as low as 7 to as high as 72% in some series (1-3). This paper is a review of our experience with pneumococcal meningitis in 43 adult patients seen during the years...References1. MCKENDRICK GP: Pneumococcal meningitis. Lancet 267: 513, 1954. MedlineGoogle Scholar2. RIBBLEBRAUDE JCAI: ACTH and adrenal steroids in the treatment of pneumococcal meningitis in adults. Amer. J. Med. 24: 68, 1958. CrossrefMedlineGoogle Scholar3. SPINKSU WWCK: Persistent menace of pneumococcal meningitis. J. A. M. A. 173: 1545, 1960. CrossrefMedlineGoogle Scholar4. WEINSTEIN L: Practice of Infectious Disease, McGraw-Hill Book Co., Inc., New York, 1958. Google Scholar5. LEPPERDOWLING MHHE: Treatment of pneumococcal meningitis with penicillin compared with penicillin plus aureomycin. Arch. Intern. Med. 88: 489, 1951. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Received for publication May 22, 1961.From the George Washington University Medical Division, District of Columbia General Hospital, and the Department of Medicine, George Washington University School of Medicine, Washington, D. C.Requests for reprints should be addressed to Monroe J. Romansky, M.D., George Washington University Hospital, 901 23d Street, N.W., Washington 7, D. C. Nextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited byBusting the Myth of “Static vs Cidal”: A Systemic Literature ReviewBeta-Lactam AntibioticsBeta-Lactam AntibioticsIn vitro activity of tigecycline in combination with gentamicin against biofilm-forming Staphylococcus aureusA risk score for unfavorable outcome in adults with bacterial meningitisPrincipes d'utilisation des antibiotiquesDoxycycline Reduces Mortality and Injury to the Brain and Cochlea in Experimental Pneumococcal MeningitisClinical Features and Prognostic Factors in Adults with Bacterial MeningitisCurrent pharmacotherapy of pneumococcal meningitisUtility of prognostic stratification in adults with community-acquired bacterial meningitisBeta-Lactam AntibioticsRisk and Case Fatality Rate of Meningitis in Patients with Liver CirrhosisA prospective study of glasgow coma scale (GCS), age, CSF-neutrophil count, and CSF-protein and glucose levels as prognostic indicators in 100 adult patients with meningitisBacterial meningitis in cirrhosis: review of 16 casesMedical-legal considerations related to symptom duration and patient outcome after bacterial meningitisClinical evaluation of pneumococcal meningitis in adults over a twelve-year periodPromptness of antibiotic therapy in acute bacterial meningitisBacterial meningitis in the patient at risk: Intrinsic risk factors and host defense mechanismsInfections in the AlcoholicPrognostic value of cytobiochemical changes in children with pyogenic meningitisIn vitro antagonism by erythromycin of the bactericidal action of antimicrobial agents against common respiratory pathogensActions of Antimicrobial Drugs in CombinationCombined Actions of Antimicrobial DrugsANTIBIOTIC COMBINATIONSSome aspects of antibacterial therapyAntimicrobial therapy in patients sensitive to penicillinPresent status of therapy with combinations of antibioticsTreatment of PyelonephritisCase 71-1963 1 October 1961Volume 55, Issue 4Page: 545-549KeywordsAntibioticsAttentionBacteremiaComaHospital medicineMeningitisMortalityPenicillinPneumococcusPneumonia Issue Published: 1 October 1961 Copyright & PermissionsCopyright, ©, 1961, by The American College of PhysiciansPDF downloadLoading ...