The Clinical Significance of Lactic Dehydrogenase Activity of Serous Effusions

Article1 April 1958THE CLINICAL SIGNIFICANCE OF LACTIC DEHYDROGENASE ACTIVITY OF SEROUS EFFUSIONSFELIX WRÓBLEWSKI, M.D., F.A.C.P., RITA WRÓBLEWSKI, M.D.FELIX WRÓBLEWSKI, M.D., F.A.C.P.Search for more papers by this author, RITA WRÓBLEWSKI, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-48-4-813 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptINTRODUCTIONObservations from tissue culture studies suggest that malignant neoplastic cells contribute increasing amounts of lactic dehydrogenase (LD) activity to the fluid medium which bathes the cells.1 Similar activity by cancer cells in vivo is implied by observations made of LD activity in the serum and the peritoneal fluid of mice with Ehrlich's ascites carcinoma.2 The generalization that malignant tissue contributes LD activity to fluids which bathe them is implied clinically by the fact that LD activity of cerebrospinal fluid is increased above the normal range in spinal fluid specimens obtained from patients with cancer, lymphoma and leukemia.3Pleural and...Bibliography1. WróblewskiMoore FAG: Unpublished observations. Google Scholar2. FriendWróblewski CF: Unpublished observations. Google Scholar3. WróblewskiDeckerWróblewski FBR: The clinical significance of alterations in lactic dehydrogenase activity in spinal fluid, N. Eng. J. Med., in press. Google Scholar4. WróblewskiLaDue FJS: Lactic dehydrogenase activity in blood, Proc. Soc. Exper. Biol. and Med. 90: 210-213, 1955. CrossrefMedlineGoogle Scholar5. PrenticeSiriJoiner TCWEE: Quantitative studies of ascitic fluid circulation with tritium-labeled water, Am. J. Med. 13: 668-673, 1952. CrossrefMedlineGoogle Scholar6. McKeeYuileLawsonWhipple FWCLBGGH: Albumin and globulin circulation in experimental ascites, J. Exper. Med. 95: 161-172, 1952. CrossrefMedlineGoogle Scholar7. WróblewskiKorngold FL: Unpublished observations. Google Scholar8. Foot NC: Identification of cells in exudates and effusates, Ann. New York Acad. Sc. 63: 1324-1330, 1956. CrossrefMedlineGoogle Scholar9. LuseReagan SAJW: A histiocytologic and electron microscopic study of effusions associated with malignant disease, Ann. New York Acad. Sc. 63: 1331-1347, 1956. CrossrefMedlineGoogle Scholar10. Foot NC: Identification of types and primary sites of metastatic tumors from exfoliated cells in serous fluids, Am. J. Path. 30: 661-677, 1954. MedlineGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, N. Y.*Received for publication April 12, 1957.From The Department of Medicine and Sloan-Kettering Institute of Memorial Center for Cancer and Allied Diseases, New York.Requests for reprints should be addressed to Felix Wróblewski, M.D., 444 East Sixty-eighth Street, New York 21, N. Y. 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ZIMMERMAN, M.D., F.A.C.P.Essentielle HypocholinesterasämieDiagnosis of Gastrointestinal CancerDètermination of Lactic Dehydrogenase in Ascitic Fluid from Patients with Malignant TumorsVergleich der Enzymaktivit�ten von Blutserum und ErgussINCREASING CLINICAL SIGNIFICANCE OF ALTERATIONS IN ENZYMES OF BODY FLUIDS*FELIX WRÓBLEWSKI, M.D.The significance of alterations in lactic dehydrogenase activity of body fluids in the diagnosis of malignant tumorsLactic Dehydrogenase Activity in Pleural and Peritoneal EffusionsTHE MECHANISMS OF ALTERATION IN LACTIC DEHYDROGENASE ACTIVITY OF BODY FLUIDS*Serum transaminase and other enzymes in acute myocardial infarctionThe Clinical Significance of Alterations in Transaminase Activities of Serum and Other Body Fluids 1 April 1958Volume 48, Issue 4Page: 813-822KeywordsAscitesBlood plasmaCellsCerebrospinal fluidDehydrogenasesLymphomaTissue cultures ePublished: 1 December 2008 Issue Published: 1 April 1958 PDF downloadLoading ...