Highlights the use of PCR/ESI-MS and specific PCR testing to confirm EV-D68 as a cause of severe pneumonia and ARDS in adults.
EV-D68 may cause ARDS in adults; case reports leave open its incidence and optimal diagnostics.
PCR/ESI-MS of BAL fluid followed by EV-D68-specific PCR testing of 1 nasopharyngeal swab and 2 BAL fluid samples confirmed our clinical suspicion of ARDS secondary to EV-D68 in an adult. The patient's history of contact with sick family members and clinical signs (nonproductive cough, nausea, and vomiting) were suggestive of a viral infection. Lessons learned from the emergence of swine-origin influenza A(H1N1)pdm09 virus and recognition (in the midst of the pandemic) that younger age and obesity were risk factors for severe disease were also suggestive of a viral respiratory infection.
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Zhang et al. (2015) studied this question.
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