Key result
Enterovirus D68 genomes sequenced from the 2016 St. Louis reemergence differed from the 2014 outbreak strains but were similar to other viruses circulating nationally in 2016.
The 2016 EV-D68 strains in St. Louis were genetically distinct from the 2014 outbreak strains but matched national circulating strains.
Supports continued EV-D68 surveillance; extends national 2016 tracking but leaves open links to clinical severity.
Enterovirus D68 (EV-D68) was rarely observed prior to a widespread outbreak in 2014. We observed its reemergence in St. Louis in 2016 and sequenced the EV-D68 genomes from two patient samples. The 2016 viruses in St. Louis differed from those we had sequenced from the 2014 outbreak but were similar to other viruses circulating nationally in 2016.
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Wylie et al. (2017) studied this question. Enterovirus D68 genomes sequenced from the 2016 St. Louis reemergence differed from the 2014 outbreak strains but were similar to other viruses circulating nationally in 2016.
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