Key result
Metagenomic sequencing of enterovirus D68 strains identified a new circulating subclade B3 with ~4.5% nucleotide divergence from 2014 outbreak strains.
Identified a new EV-D68 subclade B3 circulating in the US in 2016 with ~4.5% nucleotide divergence from the 2014 outbreak strains.
Supports EV-D68 genomic surveillance; leaves open effects on virulence, transmission, and countermeasures.
Complete genome sequences of nine enterovirus D68 (EV-D68) strains from patients in New York were obtained in 2016 by metagenomic next-generation sequencing. Comparative genomic analysis suggests that a new subclade B3, with ~4.5% nucleotide divergence from subclade B1 strains causing the 2014 outbreak, is circulating in the United States in 2016.
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Huang et al. (2016) studied this question. Metagenomic sequencing of enterovirus D68 strains identified a new circulating subclade B3 with ~4.5% nucleotide divergence from 2014 outbreak strains.
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