Key result
A biennial upsurge of EV-D68 infection was observed in New York between 2014 and 2018, characterized by the sequential emergence and circulation of subclade B1, subclade B3, and clade D viral strains.
Observational (n=2,548)
Yes
Identified a biennial upsurge and shifting molecular epidemiology of EV-D68 in New York from 2014 to 2018, providing essential data for surveillance and vaccine development.
Supports regional EV-D68 surveillance; leaves open vaccine strain selection and clinical impact pending prospective data.
= 89), demonstrating a biennial upsurge of EV-D68 infection in the study area. Ninety-one complete or nearly complete EV-D68 genome sequences were obtained. Genomic analysis of these EV-D68 strains revealed dynamics and evolution of circulating EV-D68 strains since 2014. The dominant EV-D68 strains causing the 2014 outbreak belonged to subclade B1, with a few belonging to subclade B2. New EV-D68 subclade B3 strains emerged in 2016 and continued in circulation in 2018. Clade D strains that are rarely detected in the United States also arose and spread in 2018. The establishment of distinct viral strains and their variable circulation patterns provide essential information for future surveillance, diagnosis, vaccine development, and prediction of EV-D68-associated disease prevalence and potential outbreaks.
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Gilrane et al. (2020) conducted an observational in Enterovirus D68 infection (n=2,548). Enterovirus D68 infection was evaluated on Detection and molecular epidemiology of EV-D68. A biennial upsurge of EV-D68 infection was observed in New York between 2014 and 2018, characterized by the sequential emergence and circulation of subclade B1, subclade B3, and clade D viral strains.
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