Key result
The 2016 enterovirus D68 outbreak is linked to ~18% fewer respiratory hospitalizations versus non-outbreak years.
Observational (n=22,156)
No
Ongoing surveillance and specific testing are necessary to detect enterovirus D68 outbreaks, which can vary in their impact on healthcare utilization.
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EV-D68 outbreaks may not increase respiratory hospitalizations; leaves open the need for targeted surveillance amid variable healthcare impacts.
A fall 2016 outbreak of enterovirus D68 infection in St. Louis, Missouri, USA, had less effect than a fall 2014 outbreak on hospital census, intensive care unit census, and hospitalization for a diagnosis of respiratory illness. Without ongoing surveillance and specific testing, these cases might have been missed.
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Srinivasan et al. (2018) conducted an observational in Enterovirus D68 infection (n=22,156). 2016 EV-D68 outbreak period vs. 2013 and 2015 combined (non-outbreak periods) was evaluated on Hospitalization with a respiratory diagnosis (p=0.004). During the 2016 enterovirus D68 outbreak, the percentage of patients hospitalized with a respiratory diagnosis significantly decreased to 9% compared to 11% during non-outbreak years (p=0.004).
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