Key result
Enterovirus-D68 infections in children aged 0-2 years caused acute respiratory illness in 46% of cases, of which 33% were medically attended and none required hospitalization.
Enterovirus-D68 infections in young children commonly cause acute respiratory illness requiring medical attention but rarely require hospitalization.
EV-D68 infections in healthy toddlers were mild without hospitalization; supports seasonal surveillance but leaves open severity in at-risk groups.
In this 2017-2019 community-based cohort, 245 healthy children were followed from birth to age 2 years. A total of 46 enterovirus-D68 infections were detected by nasal swabs, all occurring between August and November 2018, with no detections in other study periods. About 46% of infections met acute respiratory illness criteria, of which 33% were medically attended; none required hospitalization.
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Teoh et al. (2025) studied this question. Enterovirus-D68 infections in children aged 0-2 years caused acute respiratory illness in 46% of cases, of which 33% were medically attended and none required hospitalization.