Why the study?
Are renin-angiotensin system genetic polymorphisms associated with the presence of cerebral white matter lesions in essential hypertensive patients?
Population
60 never-treated essential hypertensive patients, aged 50 to 60 years, without clinical evidence of target…
Comparison
Renin-angiotensin system genetic polymorphisms vs Patients without the specific risk genotypes
Design
Cross-sectional
Authors
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ACE DD genotype was associated with white matter lesions in hypertension; hypothesis-generating finding leaves open genetic risk stratification.
Are renin-angiotensin system genetic polymorphisms associated with the presence of cerebral white matter lesions in essential hypertensive patients?
The ACE DD genotype and D allele are significantly associated with an increased risk of cerebral white matter lesions in patients with essential hypertension.
Sierra et al. (2002) studied this question.
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