Why the study?
Off-label medication use in pediatric populations is an important public health issue driven by a lack of gold-standard drug trials.
Highlights the widespread and often necessary use of off-label medications in pediatrics due to the lack of dedicated clinical trials.
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Off-label use in pediatrics raises safety concerns; leaves open need for targeted labeling studies in neonates and rare diseases.
Usage of off label medications in infants, children and adolescents, is an important public health issue that needs to be addressed. An overwhelming number of drugs are prescribed in every pediatric specialty without proper labeling that is essential to ensure child safety. The problem is larger and more complex in the cases of medications used in neonates, infants and children with chronic and/or rare disease. The article also emphasises that off-label use if often acceptable and is often necessitated because of a lack of gold standard drug trials in this age group.
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Unni et al. (2022) studied this question.
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