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January 5, 1979JAMA

Prophylaxis for Postoperative Deep-Vein Thrombosis

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Why the study?

Does the combination of dihydroergotamine and heparin prevent postoperative deep-vein thrombosis better than either agent alone in patients undergoing major abdominal surgery or hip replacement arthroplasty?

Population

300 patients undergoing major abdominal surgery or hip replacement arthroplasty

Comparison

Combination of dihydroergotamine and heparin vs Dihydroergotamine mesylate alone, or heparin…

Design

RCT, Randomized

Authors

VKVijay V. KakkarManipal Academy of Higher Education

Discussion

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Implication

Supports combined dihydroergotamine-heparin prophylaxis after major abdominal or hip surgery; confirms additive efficacy over monotherapy in this RCT.

Structured PICO

Does the combination of dihydroergotamine and heparin prevent postoperative deep-vein thrombosis better than either agent alone in patients undergoing major abdominal surgery or hip replacement arthroplasty?

P
Population
300 patients undergoing major abdominal surgery or hip replacement arthroplasty
I
Intervention
Combination of dihydroergotamine and heparin
C
Comparator
Dihydroergotamine mesylate alone, or heparin calcium alone
O
Outcome
Prevention of postoperative deep-vein thrombosis (DVT)hard clinical

The combination of dihydroergotamine and heparin is more effective than monotherapy for DVT prophylaxis after major abdominal or hip surgery.

Cite This Study

Vijay V. Kakkar (1979) studied this question.

synapsesocial.com/papers/6a851f8edf831772a6d69d5fhttps://doi.org/10.1001/jama.1979.03290270029015
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prophylaxis for postoperative deep-vein thrombosis. Synergistic effect of heparin and dihydroergotamine1979 · 120 citations
  2. 2Dihydroergotamine-Heparin Prophylaxis of Postoperative Deep Vein Thrombosis1984 · 72 citations
  3. 3Heparin/dihydroergotamine for venous thrombosis prophylaxis: comparison of low-dose heparin and low molecular weight heparin in hip surgery1988 · 47 citations
  4. 4Apparent Lack of Synergism between Heparin and Dihydroergotamine in Prevention of Deep Vein Thrombosis after Elective Hip Replacement: a Randomised Double-Blind Trial Reported in Conjunction with an Overview of Previous Results1992 · 8 citations
  5. 5Low molecular weight heparin plus dihydroergotamine for prophylaxis of postoperative deep vein thrombosis1986 · 61 citations