Why the study?
Does the combination of dihydroergotamine and heparin prevent postoperative deep-vein thrombosis more effectively than either agent alone in patients undergoing major abdominal surgery or hip replacement arthroplasty?
Population
300 patients undergoing major abdominal surgery or hip replacement arthroplasty
Comparison
Combination of dihydroergotamine mesylate and… vs Heparin calcium alone or dihydroergotamine…
Design
RCT, Randomized
Follow-up
postoperative
Authors
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Supports combined prophylaxis after major surgery; confirms synergistic benefit over monotherapy in RCT.
Does the combination of dihydroergotamine and heparin prevent postoperative deep-vein thrombosis more effectively than either agent alone in patients undergoing major abdominal surgery or hip replacement arthroplasty?
The combination of dihydroergotamine and heparin provides a synergistic effect, proving more effective than either agent alone for DVT prophylaxis after major surgery.
V. V. Kakkar (1979) studied this question.
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