What question did this study set out to answer?

To determine whether glucose availability modulates pulsatile luteinizing hormone (LH) secretion and whether glucoprivation directly impairs the pituitary gland or the GnRH neurosecretory system.

February 1, 1996EndocrinologyOpen Access

Metabolic interfaces between growth and reproduction. V. Pulsatile luteinizing hormone secretion is dependent on glucose availability.

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Authors

DBDavid C. BucholtzLoma Linda University NVN M VidwansUniversity of Michigan CHCristina G. HerbosaBabraham Institute

Discussion

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Implication

Animal study demonstrates that acute glucoprivation transiently suppresses pulsatile luteinizing hormone secretion in lambs, indicating central metabolic regulation upstream of GnRH neurons.

Key Points

To determine whether glucose availability modulates pulsatile luteinizing hormone (LH) secretion and whether glucoprivation directly impairs the pituitary gland or the GnRH neurosecretory system.
Monitored LH pulses in gonadectomized male lambs on limited artificial milk diets following intravenous administration of the glucose antagonist 2-deoxyglucose (2DG) at 60, 120, 240, and 480 mg/kg.
Challenged the pituitary and GnRH neurosecretory systems during 2DG-induced glucoprivation using exogenous GnRH and the secretagogue N-methyl-D,L-aspartate (NMA).
Administered 2DG directly into the lateral cerebral ventricle at 1/100th of peripheral doses to evaluate central site-specific action and plasma glucose changes.
Peripheral 2DG at 240 and 480 mg/kg transiently suppressed LH pulse frequency without altering pulse amplitude, whereas lower doses (60 and 120 mg/kg) produced no effect.
Treatment with either GnRH or NMA during peripheral glucoprivation prevented the suppression of LH pulse frequency, maintaining secretion at pre-treatment levels.
Central 2DG delivery across all tested doses transiently reduced LH pulse frequency without altering pulse amplitude or changing peripheral plasma glucose levels.

Cite This Study

Bucholtz et al. (1996) studied this question.

synapsesocial.com/papers/6a8523ef918170c1666e0fee https://doi.org/10.1210/endo.137.2.8593808

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Implication

Animal study demonstrates that acute glucoprivation transiently suppresses pulsatile luteinizing hormone secretion in lambs, indicating central metabolic regulation upstream of GnRH neurons.

Metabolic interfaces between growth and reproduction. V. Pulsatile luteinizing hormone secretion is dependent on glucose availability.

Discussion

Member takes

Implication

Key Points

Cite This Study

Metabolic interfaces between growth and reproduction. V. Pulsatile luteinizing hormone secretion is dependent on glucose availability.

Discussion

Member takes

Implication

Key Points

Cite This Study

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