Key result
Administration of 2-deoxy-D-glucose in ovariectomized ewes significantly suppressed serum concentrations of LH (p < 0.05) without affecting growth hormone, prolactin, or IGF-I levels.
Population
Mature, ovariectomized, crossbred ewes
Comparison
2-deoxy-D-glucose 0.1 g/kg BW single s.c… vs Saline single s.c. injection
Design
Preclinical
Follow-up
2 hours
Authors
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Does not support clinical modulation of LH via glucose antagonism; leaves open metabolic gating of gonadotropins in other species.
p-value: p=<0.05
Acute glucose antagonism with 2DG suppresses LH release in ewes, likely via hypothalamic actions, without altering IGF-I or IGFBP concentrations.
Funston et al. (1995) studied Healthy (animal model). 2-deoxy-D-glucose (2DG) vs. Saline was evaluated on Serum concentrations of LH (p=<0.05). Administration of 2-deoxy-D-glucose in ovariectomized ewes significantly suppressed serum concentrations of LH (p < 0.05) without affecting growth hormone, prolactin, or IGF-I levels.
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