August 1, 2000Journal of EndocrinologyOpen Access

IGF-I stimulation of luteinizing hormone secretion, IGF-binding proteins (IGFBPs) and expression of mRNAs for IGFs, IGF receptors and IGFBPs in the ovine pituitary gland

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Population

Ovine pituitary gland tissue

Comparison

IGF-I or luteinizing hormone-releasing hormone… vs Basal conditions (no stimulation)

Design

Preclinical

Authors

CACL Adam TGTS GaddRoyal Veterinary College PFP. A. FindlayUniversity of Aberdeen

Discussion

Member takes

Implication

Supports direct pituitary LH stimulation by IGF-I in sheep; leaves open translational relevance to nutritional puberty modulation in other species.

Structured PICO

Population

Ovine pituitary gland tissue (coronal hypothalamic and pituitary sections from pubertal ewe lambs, pars distalis extracts from male castrates, and cultured pars distalis cells from abattoir-killed sheep)

Intervention

IGF-I (0.1, 1, 10 or 30 nM) or luteinizing hormone-releasing hormone (LHRH, 10 nM) alone, or both together

Comparator

Basal conditions (no stimulation)

Outcome

Luteinizing hormone (LH) secretion, localization of IGF-I binding, and gene expression for components of the IGF systemsurrogate

An intrapituitary IGF system exists in sheep, and IGF-I stimulates LH secretion at the pituitary level, suggesting an endocrine role in nutritional modulation of puberty.

Cite This Study

Adam et al. (2000) studied this question.

synapsesocial.com/papers/6a722dabe5469ee92be24d40 https://doi.org/10.1677/joe.0.1660247

View Full Paper

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Implication

Supports direct pituitary LH stimulation by IGF-I in sheep; leaves open translational relevance to nutritional puberty modulation in other species.

IGF-I stimulation of luteinizing hormone secretion, IGF-binding proteins (IGFBPs) and expression of mRNAs for IGFs, IGF receptors and IGFBPs in the ovine pituitary gland

Discussion

Member takes

Implication

Structured PICO

Cite This Study

IGF-I stimulation of luteinizing hormone secretion, IGF-binding proteins (IGFBPs) and expression of mRNAs for IGFs, IGF receptors and IGFBPs in the ovine pituitary gland

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider