Cellular localization and expression of insulin-like growth factors (IGFs) and IGF binding proteins within the epiphyseal growth plate of the ovine fetus: possible functional implications

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Structured PICO

Population

Fetal sheep epiphyseal growth plates and monolayer cultures of chondrocytes from the proliferative zone

Intervention

Exogenous IGFBP-2, -3, -4, -5, Long R3 IGF-I, and native IGF-I

Outcome

Cellular distribution and expression of IGFs and IGFBPs, and DNA synthesis in chondrocyte culturessurrogate

Locally produced IGF-II and circulating IGF-I may influence fetal epiphyseal chondrogenesis, modulated locally by multiple IGFBPs.

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Should not change clinical practice in growth disorders; leaves open IGFBP modulation of human fetal chondrogenesis.

Rios et al. (1999) studied this question.

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