Key result
A five-day maternal fast decreased IGF-I and IGF-II levels by 88% and 32% in maternal circulation and by 41% and 16% in fetal circulation.
Effect estimate: decreased by 41%
p-value: p=<0.006
In the ovine fetus, circulating IGFs and IGFBPs are sensitive to prolonged nutrient deficit (maternal fasting) and exogenous IGF-I, but not to brief glucose increases, suggesting nutritional status regulates the fetal IGF system.
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Ovine data link maternal fasting to fetal IGF suppression; hypothesis-generating and should not yet inform human pregnancy management.
Lee et al. (1997) studied Pregnancy (ovine model) (n=8). Maternal fasting vs. Fed state (baseline) was evaluated on Fetal circulating IGF-I levels (decreased by 41%, p=<0.006). A five-day maternal fast decreased IGF-I and IGF-II levels by 88% and 32% in maternal circulation and by 41% and 16% in fetal circulation.
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