April 22, 2005Endocrinology

Insulin-Like Growth Factor (IGF)-I Stimulates Cell Proliferation and Induces IGF Binding Protein (IGFBP)-3 and IGFBP-5 Gene Expression in Cultured Growth Plate Chondrocytes via Distinct Signaling Pathways

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Population

Two cell culture models of rat growth plate chondrocytes

Design

Preclinical

Authors

DKDaniela KiepeBambino Gesù Children's Hospital SCSonia CiarmatoriHeidelberg University AHAndreas HoeflichResearch Institute for Farm Animal Biology (FBN)

Discussion

Member takes

Implication

Rat chondrocyte data on IGF-I pathway selectivity warrant no clinical action; leaves open human validation and therapeutic targeting.

Structured PICO

Population

Two cell culture models of rat growth plate chondrocytes (primary culture and mesenchymal chondrogenic cell line RCJ3.1C5.18)

Intervention

Incubation with IGF-I, with or without specific inhibitors of the p42/44 MAPK pathway (PD098059 or U0126) or phosphatidylinositol-3 kinase signaling pathway (LY294002)

Outcome

IGFBP-3 and IGFBP-5 concentrations and mRNA expressionsurrogate

IGF-I uses different and partially overlapping intracellular signaling pathways to regulate the synthesis of IGFBP-3 and IGFBP-5 in rat growth plate chondrocytes.

Cite This Study

Kiepe et al. (2005) studied this question.

synapsesocial.com/papers/6a7d4f4858b935a3e446dae5 https://doi.org/10.1210/en.2005-0324

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Insulin-Like Growth Factor (IGF)-I Stimulates Cell Proliferation and Induces IGF Binding Protein (IGFBP)-3 and IGFBP-5 Gene Expression in Cultured Growth Plate Chondrocytes via Distinct Signaling Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Insulin-Like Growth Factor (IGF)-I Stimulates Cell Proliferation and Induces IGF Binding Protein (IGFBP)-3 and IGFBP-5 Gene Expression in Cultured Growth Plate Chondrocytes via Distinct Signaling Pathways

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider