July 1, 1998Biology of ReproductionOpen Access

Estradiol Increases Relative Amounts of Insulin-Like Growth Factor Binding Protein (IGFBP)-3 in Serum and Expression of IGFBP-2 in Anterior Pituitaries of Ewes1

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Population

Ovariectomized ewes during the anestrous season

Comparison

Estradiol implant vs No implant

Design

Preclinical

Follow-up

80 days

Authors

JCJ. A. ClapperSouth Dakota State University JSJ.L. SnyderUniversity of Wyoming ARA. J. RobertsUnited States Army Medical Command

Discussion

Member takes

Implication

Animal findings in sheep do not inform human care; leaves open whether IGF alterations mediate estradiol effects on gonadotrophs.

Structured PICO

Population

Ovariectomized ewes during the anestrous season

Intervention

Estradiol implant

Comparator

No implant

Outcome

Levels of insulin-like growth factor (IGF)-I and IGF binding proteins (IGFBPs) in the pituitary gland, hypophyseal stalk median eminence (SME), and circulation, and LH levelssurrogate

Estradiol influences both the IGF and gonadotropin systems in sheep, suggesting its effects on gonadotroph function may be mediated by alterations in the IGF system.

Cite This Study

Clapper et al. (1998) studied this question.

synapsesocial.com/papers/6a8b0ddbf19228bbb2fb45c7 https://doi.org/10.1095/biolreprod59.1.124

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Estradiol Increases Relative Amounts of Insulin-Like Growth Factor Binding Protein (IGFBP)-3 in Serum and Expression of IGFBP-2 in Anterior Pituitaries of Ewes1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Estradiol Increases Relative Amounts of Insulin-Like Growth Factor Binding Protein (IGFBP)-3 in Serum and Expression of IGFBP-2 in Anterior Pituitaries of Ewes1

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider