Why the study?
Does recombinant virus vMLN450 elicit an immune response against HIV-1 in mice and monkeys?
Population
Mice and cynomolgus monkeys
Design
Preclinical
Authors
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Supports vMLN450 as HIV-1 vaccine vector in primates; leaves open human immunogenicity, durability, and protection.
Does recombinant virus vMLN450 elicit an immune response against HIV-1 in mice and monkeys?
Attenuated Mengo virus can serve as an effective expression vector to elicit immune responses against HIV-1, offering a potential approach for live recombinant vaccines.
Altmeyer et al. (1994) studied this question.
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