March 1, 2003HypertensionOpen Access

Characterization of a New Selective Antagonist for Angiotensin-(1–7), d -Pro 7 -Angiotensin-(1–7)

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Population

Preclinical models including mouse aorta, water-loaded rats, mouse kidney slices, Chinese hamster ovary…

Comparison

D-Pro7-Ang-(1-7) vs Ang-(1-7) alone, Ang II alone, or bradykinin alone

Design

Preclinical

Authors

RSRobson A.S. SantosGeneral Cardiology AHAndréa Siqueira HaibaraUniversidade Federal de Minas Gerais MCMaria José Campagnole‐SantosGeneral Cardiology

Discussion

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Implication

D-Pro7-Ang-(1-7) enables selective Ang-(1-7) blockade in models; leaves open clinical translation in hypertension.

Structured PICO

Population

Preclinical models including mouse aorta, water-loaded rats, mouse kidney slices, Chinese hamster ovary cells stably transfected with AT1 receptor, and adrenal medulla membrane preparations.

Intervention

D-Pro7-Ang-(1-7)

Comparator

Ang-(1-7) alone, Ang II alone, or bradykinin alone

Outcome

Inhibition of Ang-(1-7)-induced physiological effects (hypertensive effect, vasorelaxation, antidiuresis) and receptor bindingsurrogate

D-Pro7-Ang-(1-7) is a selective antagonist for Ang-(1-7) that can be used to study the functional role of this peptide.

Cite This Study

Santos et al. (2003) studied this question.

synapsesocial.com/papers/6a85274bdf831772a6d69e2f https://doi.org/10.1161/01.hyp.0000052947.60363.24

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Characterization of a New Selective Antagonist for Angiotensin-(1–7), d -Pro 7 -Angiotensin-(1–7)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Characterization of a New Selective Antagonist for Angiotensin-(1–7), d -Pro 7 -Angiotensin-(1–7)

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider