Why the study?
Is the ACE gene I/D polymorphism associated with psoriasis or psoriatic arthritis?
Is the ACE gene I/D polymorphism associated with psoriasis or psoriatic arthritis?
The ACE insertion/deletion polymorphism is not associated with psoriasis or psoriatic arthritis in the Spanish population.
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ACE I/D polymorphism testing adds no value to psoriasis risk assessment; leaves open associations with severity or other populations for targeted study.
Data on the potential influence of the angiotensin-converting enzyme (ACE) insertion/ deletion (I/D) genotype on psoriasis are contradictory. Our aim was to investigate the relationship between the ACE gene I/D polymorphism and psoriasis/psoriatic arthritis. To investigate this, a genetic association study was conducted among 268 unrelated patients with psoriasis and 272 controls. The distribution of DD, ID, and II genotypes did not significantly differ between psoriatic patients and controls (DD: 39.6% vs. 34.2%; ID: 46.3% vs. 53.3%; II: 14.1% vs. 12.5%). In conclusion, the ACE polymorphism is not likely to be associated with either psoriasis or psoriatic arthritis in this study.
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Coto‐Segura et al. (2009) studied this question.
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