Why the study?
Are renin-angiotensin system gene polymorphisms associated with premature coronary heart disease in a Turkish population?
Population
243 Turkish individuals, comprising 115 patients with premature coronary heart disease (CHD) and 128 controls.
Comparison
Presence of renin-angiotensin system gene… vs Controls without premature CHD, or individuals…
Design
Case-control
Authors
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These associations are hypothesis-generating in a Turkish cohort; prospective validation required before any clinical application.
Are renin-angiotensin system gene polymorphisms associated with premature coronary heart disease in a Turkish population?
ACE DD and AGT MM genotypes are associated with an increased risk of premature coronary heart disease in the Turkish population.
Şekuri et al. (2005) studied this question.