Why the study?
Does the concurrent carrier status of the 4G allele of the plasminogen activator inhibitor gene and the PlA2 allele of the glycoprotein IIIa gene increase the risk of myocardial infarction in the Finnish population?
Population
Patients with a history of myocardial infarction and carefully matched controls from the Finnish population.
Comparison
Carrier status of the 4G allele of the… vs Non-carriers or matched controls.
Design
Cross-sectional
Authors
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Concurrent variant carriage was associated with higher MI risk in men; hypothesis-generating and should not yet change practice.
Does the concurrent carrier status of the 4G allele of the plasminogen activator inhibitor gene and the PlA2 allele of the glycoprotein IIIa gene increase the risk of myocardial infarction in the Finnish population?
The concurrent presence of the 4G allele of the plasminogen activator inhibitor gene and the PlA2 allele of the glycoprotein IIIa gene confers an additive and significantly increased risk of myocardial infarction, particularly in men.
Tomi Pastinen (1998) studied this question.
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