Why the study?
Human genetic factors contributing to the high transmissibility and progressive disease of COVID-19 were largely unknown.
Population
~ 81,000 human genomes
Comparison
DNA polymorphisms in ACE2 and TMPRSS2 across different populations
Authors
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Hypothesis-generating for genetic COVID-19 susceptibility; leaves open validation before any clinical risk stratification.
ACE2 and TMPRSS2 DNA polymorphisms may explain differential genetic susceptibility to COVID-19 across populations and risk groups.
Hou et al. (2020) studied this question.
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