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February 22, 2022European journal of medical researchOpen Access

Polymorphisms and mutations of ACE2 and TMPRSS2 genes are associated with COVID-19: a systematic review

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Key result

Polymorphisms and mutations in the ACE2 (10 SNPs, 21 mutations) and TMPRSS2 (13 SNPs, 12 variants) genes are strongly associated with vulnerability, intensity, and clinical outcomes of COVID-19.

Why the study?

Do polymorphisms and mutations in ACE2 and TMPRSS2 genes affect susceptibility to COVID-19 and patient prognosis?

Population

33,923 patients with COVID-19 drawn from the general population and deriving from over 160 regions and 50…

Design

Systematic_review

Authors

JLJingwei LiAffiliated Hospital of Shandong University of Traditional Chinese MedicineYWYali WangNorth Sichuan Medical UniversityYLYong LiuHubei University of Medicine

Discussion

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Implication

May inform genetic risk stratification for COVID-19; leaves open prospective validation before guiding personalized therapies.

Study Design

Type

Systematic Review (n=593,923)

Structured PICO

Do polymorphisms and mutations in ACE2 and TMPRSS2 genes affect susceptibility to COVID-19 and patient prognosis?

P
Population
33,923 patients with COVID-19 and approximately 560,000 samples from global genetic databases were included to assess the effect of ACE2 and TMPRSS2 polymorphisms on COVID-19 susceptibility and prognosis.
E
Exposure
Polymorphisms and mutations in ACE2 and TMPRSS2 genes
O
Outcome
Susceptibility to COVID-19 and patient prognosis

Polymorphisms and mutations in ACE2 and TMPRSS2 genes are associated with COVID-19 susceptibility and prognosis, highlighting potential targets for personalized medicine.

Limitations

  • Did not perform a meta-analysis utilizing forest plots due to expected heterogeneity of the study design, analytic model, and measurements.
  • Did not analyze study bias based on the diversity of included studies.
  • Additional large-sample, multicenter clinical studies are required to validate findings.

Cite This Study

Li et al. (2022) conducted a systematic review in COVID-19 (n=593,923). ACE2 and TMPRSS2 gene polymorphisms and mutations vs. Wild-type or reference genotypes was evaluated on Association of ACE2 and TMPRSS2 polymorphisms with COVID-19 susceptibility and prognosis. Polymorphisms and mutations in the ACE2 (10 SNPs, 21 mutations) and TMPRSS2 (13 SNPs, 12 variants) genes are strongly associated with vulnerability, intensity, and clinical outcomes of COVID-19.

synapsesocial.com/papers/6ab394357a8b04860e295c83https://doi.org/10.1186/s40001-022-00647-6

Topics

COVID-19 cardiovascular
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Analysis of the Spectrum of ACE2 Variation Suggests a Possible Influence of Rare and Common Variants on Susceptibility to COVID-19 and Severity of Outcome2020 · 42 citations
  2. 2Time-lapse sentinel surveillance of SARS-CoV-2 spread in India2020 · 3 citations
  3. 3The scRNA-seq Expression Profiling of the Receptor ACE2 and the Cellular Protease TMPRSS2 Reveals Human Organs Susceptible to SARS-CoV-2 Infection2021 · 130 citations
  4. 4Genetic Association of ACE2 rs2285666 Polymorphism With COVID-19 Spatial Distribution in India2020 · 118 citations