May 1, 1998Anesthesiology

Ketorolac and Enoxaparin Affect Arterial Thrombosis and Bleeding in the Rabbit

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Why the study?

Does ketorolac and/or enoxaparin reduce arterial thrombosis in a rabbit model?

Population

Rabbit model of arterial thrombosis and bleeding (n=40)

Comparison

Ketorolac, enoxaparin, or ketorolac plus… vs Control group (intravenous infusion)

Design

Preclinical, randomly assigned, blinded

Follow-up

20-min periods

Authors

SDS. Delaporte-CerceauSorbonne Université CSCharles Marc SamamaVascular Medicine BRBruno RiouCross-Cutting Cardiology

Discussion

Member takes

Implication

Ketorolac may reduce arterial thrombosis in rabbit models; clinical translation remains untested and should not yet change practice.

Structured PICO

Does ketorolac and/or enoxaparin reduce arterial thrombosis in a rabbit model?

Population

Rabbit model of arterial thrombosis and bleeding (n=40)

Intervention

Ketorolac (2 mg/kg IV), enoxaparin (0.5 mg/kg IV), or ketorolac plus enoxaparin (2 mg/kg and 0.5 mg/kg IV)

Comparator

Control group (intravenous infusion)

Outcome

Number of cyclic flow reductions (CFRs) occurring in a 20-min period (measure of treatment and prevention effect)surrogate

Ketorolac exhibits significant antithrombotic activity in a rabbit model, while its combination with enoxaparin increases bleeding time.

Cite This Study

Delaporte-Cerceau et al. (1998) studied this question.

synapsesocial.com/papers/6a852e7de1eabc68e2928ea7 https://doi.org/10.1097/00000542-199805000-00023

Topics

Dual antiplatelet therapy

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Ketorolac and Enoxaparin Affect Arterial Thrombosis and Bleeding in the Rabbit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Ketorolac and Enoxaparin Affect Arterial Thrombosis and Bleeding in the Rabbit

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider