Lack of Inhibitory Effect of α-Human Atrial Natriuretic Polypeptide on Aldosteronogenesis in Aldosterone-Producing Adenoma*

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Structured PICO

Population

Normal adrenal cells and aldosterone-producing adenoma (APA) cells in primary monolayer cultures

Intervention

Synthetic alpha-human atrial natriuretic polypeptide (alpha hANP)

Comparator

Normal adrenal cells vs APA cells

Outcome

Aldosterone secretion and intracellular cGMP accumulationsurrogate

The lack of inhibitory effect of alpha hANP on aldosteronogenesis in APA cells is likely due to the absence of specific receptor sites.

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alpha hANP lacks effect on APA cells; leaves open receptor-targeted strategies for primary aldosteronism.

Higuchi et al. (1986) studied this question.

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